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. 2005 Dec;103:69–74.

TABLE.

OVERVIEW OF FOUR CASES OF NECROBIOTIC XANTHOGRANULOMA AND TWO CASES OF ADULT-ONSET XANTHOGRANULOMA

CASE NO. AGE/SEX DX ASSOCIATED SYSTEMIC DISEASE SYMPTOMS AND SIGNS DURATION OF SYMPTOMS AND SIGNS (MONTHS) INVOLVED SITE ORBITAL INVOLVEMENT TRIAMCINOLONE DOSE NO. OF INJECTIONS RESPONSE COMPLICATION FOLLOW-UP (MONTHS)
1 60/M NXG None Nodularity, discoloration, diplopia, swelling, ptosis 32.0 Bilateral Bilateral superoanterior 40 mg 22 Improved nodularity, discoloration, ptosis None 86
2 54/M NXG NHL Nodularity, discoloration, diplopia 1.5 Bilateral Unknown 40 mg 2 Improved nodularity None 3
3 73/F NXG MGUS Nodularity, discoloration, diplopia, proptosis, ptosis, pain 6.0 Bilateral Left superoanterior 30 to 120 mg 9 Improved nodularity, discoloration, diplopia None 37
4 41/M NXG CLL, MDS Nodularity, discoloration, proptosis, swelling 60.0 Bilateral Bilateral superoanterior and EOM 30 mg 1 Stable None 96 (died of CLL)
5 34/F AXG Eczema Nodularity, discoloration, proptosis 24.0 Bilateral Bilateral superoanterior 32 to 70 mg 3 Improved all signs None 46
6 57/F AXG None Nodularity, discoloration, diplopia, proptosis, ptosis 48.0 Right Superoanterior 40 to 90 mg 2 Improved all signs None 30

AXG = adult-onset xanthogranuloma; CLL = chronic lymphocytic leukemia; Dx = diagnosis; EOM = extraocular muscles; MDS = myelodysplastic syndrome; MGUS = monoclonal gammopathy of uncertain significance; NHL = non-Hodgkin’s lymphoma; NXG = necrobiotic xanthogranuloma.