FIGURE 11B.

High-dose hyaluronidase effects on hyaluronan solutions. Each point represents the average of five separate specimens, and the error bars are the standard error of the mean. The statistical analyses compare each point to time zero, and statistical significance is indicated by the red asterisks. The high dose of hyaluronidase decreased average particle size (arbitrary units) by about 50% (P < .001). The effect was apparent at 2 hours and remained statistically significant throughout the study period of 24 hours.