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Loss of X mutants during a single generation in populations propagated in the presence and absence of co-infection. Each point is the back-transformed least-squares mean frequency (±95% C.I.) of three replicate populations evolved at MOI = 5 (triangles) or MOI = 0.001 (squares). Populations were initially composed of wt virus and three single mutants (X/+/+, +/h/+, and +/+/ts) in equal proportion. Data show stronger selection against mutants in the absence of co-infection.
