Table 1.
Selective inhibition of TNF-alpha by LMP-420
| CYTOKINE | LPS-Stimulated Release (pg/ml) | Percent Inhibition | |
| Media Alone | + LMP-420 (1 μM) | ||
| IL-1β | 15, 829 ± 75 | 10,670 ± 271 | 33 |
| IL-2 | 24 ± 0 | 18 ± 1 | 25 |
| IL-4 | 582 ± 54 | 419 ± 13 | 28 |
| IL-5 | 7 ± 3 | 3 ± 1 | 57 |
| IL-6 | 16,512 ± 190 | 17,249 ± 103 | 0 |
| IL-7 | 26 ± 1 | 24 ± 1 | 8 |
| IL-8 | 17,160 ± 221 | 17,575 ± 262 | 0 |
| IL-10 | 1,963 ± 17 | 1,766 ± 62 | 10 |
| IL-12 | 51 ± 3 | 76 ± 4 | 0 |
| IL-13 | 44 ± 2 | 33 ± 0 | 25 |
| IL-17 | 80 ± 1 | 56 ± 1 | 30 |
| G-CSF | 2,861 ± 98 | 4,794 ± 803 | 0 |
| GM-CSF | 93 ± 6 | 63 ± 4 | 32 |
| MCP-1 | 2,714 ± 132 | 143 ± 0 | 95 |
| MIP-1β | 19,554 ± 63 | 19,127 ± 520 | 2 |
| IFN-γ | 424 ± 4 | 262 ± 1 | 38 |
| TNF-α | 7,628 ± 112 | 654 ± 7 | 91 |