TABLE 4—

Odds Ratios (95% Confidence Intervals) for Coronary Heart Disease Comparing Childhood Manual Social Class With Nonmanual Social Class

Variables Included in Fully Adjusted Model	Number With Complete Data on All Variables Included in Fully Adjusted Model	Age- and Adult-SES-Adjusted OR (95% CI)	Fully Adjusted OR (95% CI)	Percentage Decrease in OR With Full Adjustment
Components of the insulin resistance syndromea	2986	1.34 (1.03, 1.75) P = .02	1.21 (0.92, 1.58) P = .18	38
Behavioral risk factorsb	3410	1.35 (1.08, 1.68) P = .005	1.25 (0.98, 1.59) P = .07	29
Biomarkers of early-life environmental exposuresc	3363	1.36 (1.08, 1.68) P = .005	1.18 (0.92, 1.48) P = .30	50
Indicators of anxiety/depressiond	3414	1.36 (1.10, 1.69) P < .001	1.35 (1.10, 1.68) P = .002	2.8
All potential explanatory factorse	2842	1.34 (1.03, 1.74) P = .02	1.13 (0.85, 1.49) P = .41	62

Note. OR = odds ratio; CI = confidence interval; SES = socioeconomic status (adult SES factors adjusted for adult social class, adult housing status, car ownership, and pension arrangements); HOMA = homeostasis model assessment (of insulin resistance); FEV₁ = forced expiratory volume in 1 second.

^aHigh-density lipoprotein cholesterol, triglycerides, systolic blood pressure, diastolic blood pressure, waist to hip ratio, body mass index (all continuous variables), HOMA score-type 2 diabetes categories (first 5 categories quintiles of HOMA score, sixth category type 2 diabetes).

^bSmoking status (never, ex, or current at 1 of 4 levels: 1–9, 10–19, 20–29, or ≥ 30 cigarettes per day) and physical activity (none, < 1, 1–2, ≥ 2 hours per week of moderate or vigorous physical activity).

^cLeg length, FEV₁ (continuous variables).

^dCurrently feel moderately or extremely anxious and/or depressed, ever been diagnosed by a doctor with depression, currently uses anxiolytics, hypnotics, or antidepressants (all binary).

^eAll variables included in models a–d.