. 2006 Apr;44(4):1382–1389. doi: 10.1128/JCM.44.4.1382-1389.2006

TABLE 1.

Clinical findings and genotype analysis in congenitally infected fetuses and infants with T. gondii^a

Case no.	Mother's serology		Symptomatic vs. asymptomatic congenital toxoplasmosis			Perinatal diagnosis			Genotype		Serotype
Case no.	GW	Anti-T. gondii antibodies	GW/NP	Clinical findings	IUD, GW/NP	PCR	MI	NS	Sample	T. gondii type	Serum	T. gondii type
1	34	IgG⁺, IgM⁺, IgA⁺	<35	Hydrocephaly		Pos.	Pos.	IgG⁺	CSF	II	Mother	II
		IgG avidity low	NP	Chorioretinitis				IgM⁺			Infant	II
								IgA⁺
2	12	IgG⁻, IgM⁻		Asymptomatic		Pos.	Pos.	IgG⁺	AF	II	Mother	Uncertain
	31	IgG⁻, IgM⁺						IgM⁺			Infant	II
	38	IgG⁺, IgM⁺, IgA⁺						IgA⁺
3	27	IgG⁺, IgM⁺, IgA⁺	29	Hydrocephaly	IUD, 32	Pos.	Pos.	ND	AF	II	Mother	II
		IgG avidity low									Infant	II
4	35	IgG⁺, IgM⁺, IgA⁺	32	Hydrocephaly	NP	Pos.	Pos.	IgG⁺	AF	II	Mother	II
		IgG avidity low						IgM⁺			Infant	II
								IgA⁻
5	27	IgG⁺, IgM⁺, IgA⁺	27	Ventriculomegaly		Pos.	Pos.	IgG⁺	AF	II	Mother	II
		IgG avidity low						IgM⁺			Infant	II
								IgA⁺
6	29	IgG⁺, IgM⁺, IgA⁺	28	Hydrocephaly	IUD, 35	Pos.	Pos.	ND	AF	II	Mother	II
		IgG avidity low									Infant	NA
7	28	IgG⁺, IgM⁺, IgA⁻	27	Hydrocephaly		Pos.	Pos.	IgG⁺	AF	II	Mother	II
		IgG avidity low	NP	Chorioretinitis				IgM⁺			Infant	NA
								IgA⁺
8	32	IgG⁺, IgM⁺, IgA⁺	27	Hydrocephaly	NP	Pos.	ND	IgG⁺	AF	II	Mother	NA
			NP	Choroidoretinitis				IgM⁺			Infant	NA
								IgA⁺
9	34	IgG⁺, IgM⁺, IgA⁺	28	Ventriculomegaly		Pos.	ND	IgG⁺	AF	II	Mother	NA
		IgG avidity low	NP	Chorioretinitis				IgM⁺			Infant	NA
								IgA⁺
10	28	IgG⁺, IgM⁺, IgA⁺	<28	Hydrocephaly		ND	ND	IgG⁺	CSF	NT	Mother	NA
		IgG avidity low						IgM⁺			Infant	NA
								IgA⁺
11	13	IgG⁺, IgM⁺, IgA⁺		Asymptomatic		Pos.	Pos.	IgG⁺	AF	NT	Mother	II
		IgG avidity low						IgM⁻			Infant	II
								IgA⁻
12	20	IgM⁺		Asymptomatic		Pos.	Pos.	IgG⁺	AF	NT	Mother	II
	25	IgG⁺, IgM⁺, IgA⁺						IgM⁻			Infant	II
		IgG avidity low						IgA⁻
13	30	IgG⁺, IgM⁺, IgA⁻		Asymptomatic		Pos.	Pos.	IgG⁺	AF	NT	Mother	Uncertain
		IgG avidity low						IgM⁻			Infant	Uncertain
								IgA⁻
14	28	IgG⁺, IgM⁺, IgA⁺		Asymptomatic		Neg.	Pos.	IgG⁺	AF	NT	Mother	Uncertain
		IgG avidity low						IgM⁻			Infant	II
								IgA⁻
15	27	IgG⁺, IgM⁺, IgA⁺		Asymptomatic		Pos.	Neg.	IgG⁺	AF	NT	Mother	Atypical
		IgG avidity low						IgM⁺			Infant	Atypical
								IgA⁺
16	30	IgG⁺, IgM⁺, IgA⁺		Asymptomatic		ND	ND	IgG⁺	NB	NT	Mother	NA
								IgM⁺			Infant	NA
								IgA⁺
17	15	IgG⁺, IgM⁺, IgA⁺		Asymptomatic		ND	ND	IgG⁺	NB	NT	Mother	Atypical
		IgG avidity low						IgM⁺			Infant	Atypical
								IgA⁻
18	32	IgG⁺, IgM⁺, IgA⁻	29	Hydrocephaly		Pos.	ND	IgG⁺	NB	NT	Mother	II
		IgG avidity high						IgM⁺			Infant	II
								IgA⁻
19	31	IgG⁺, IgM⁺, IgA⁺	31	Hydrocephaly	NP	ND	ND	IgG⁺	AF	NT	Mother	II
		IgG avidity low						IgM⁺			Infant	II
								IgA⁺

Abbreviations: GW, gestational week; NP, neonatal period; IUD, intrauterine death; MI, mouse inoculation; NS, neonatal serology; pos., positive result; neg., negative; ND, not done; NT, nontypeable; NA, not available; NB, neonatal blood. Mothers' serology results are given for the first available test. CSF was used for PCR or mouse inoculation in cases 1 and 18 and AF was used in the remaining cases. Uncertain refers to low values with all peptides, such that a strain type could not be reliably determined. Atypical refers to the reaction with peptides from different strain types, reflecting either mixed infection or possibly unusual genotypes. The tests used and their cutoff values are given in the text.