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Differences in antihypertensive efficacy between irbesartan 150 mg and valsartan 80 mg in monotherapy are sustained in hydrochlorothiazide (HCTZ) combination therapy: results from the COSIMA study (Reproduced with permission from Bobrie G, et al. Am J Hypertens 2005; 18: 1482–8(41)). Mean morning and evening BP decrease (mm Hg) measured by Home BP Measurements. p < 0.01 for all values except SBP evening (p = 0.065). Intent-to-treat analysis.
