Table 1.

Pharmacokinetic and pharmacologic parameters of angiotensin receptor blockers (35–39)

	Standard dose range (mg)	Half-life (h)	Volume of distribution (l)	Bioavailability (%)	Receptor binding
Losartan	50–100	2 (6–9)*	34 (12)*	33	Competitive (insurmountable)*
Valsartan	80–160 (maximum 320)	6	17	25	Competitive
Irbesartan	150–300	11–15	53–93	60–80	Insurmountable
Candesartan	8–32	9–12	0.13 L/kg	15	Insurmountable
Telmisartan	20–80	24	500	42–58	Insurmountable
Olmesartan	20–40	13	17	26	Insurmountable
Eprosartan	400–800	5–7	13	13	Insurmountable

^*EXP 3171 active metabolite of losartan.