Figure 1.—

(A) A schematic of PDK1-related proteins. The solid box indicates the conserved catalytic domain sequences. The open box shows conserved PH domain sequences. (B) Sequence alignment of the activation loop of putative Ksg1 substrates in fission yeast. (+) identical amino acids; (:) similar amino acids. The accession numbers for the indicated proteins are Pka1, BAA04891 (Maeda et al. 1994); Sck1, S55694 (Jin et al. 1995); Sck2, CAA93901 (Fujita and Yamamoto 1998); Pck1, P36582 (Yonemoto et al. 1993); and Pck2, P36583 (Yonemoto et al. 1993).