Figure 1.—

The synthetic lethality of mec-8 and sym-2. (A) Nomarski image of an embryo arrested at the twofold stage that segregated from a strain having the genotype mec-8(u74); rol-6 unc-4/sym-2. (B) Image of a developmentally arrested embryo that segregated from a mec-8(u314) homozygote following injection of dsRNA derived from part of the first and third exons and all of the second exon of the sym-2 gene. Injection of mec-8(u74) homozygotes with the same dsRNA produced the same effect. Bar, 25 μm.