Figure 6.—

The amino-terminal half but not the carboxyl-terminal half of SYM-3A is similar to the amino-terminal parts of proteins of unknown function from other species. The amino acid sequences of proteins from Drosophila (GenBank no. NM136259), mosquito (Anopheles gambiae; GenBank XM-318591), and mouse (GenBank NM 153560) are aligned. The proteins, which are shown in their entirety, are longer than SYM-3A and resemble each other outside the region of similarity with SYM-3A. The proteins least resemble each other in their middle parts, which correspond to the carboxyl-terminal half of SYM-3A. The location and consequence of the mn618 mutation are indicated. The fourth row of the alignment includes the final four amino acids predicted for SYM-3B, which is otherwise identical with SYM-3A up to this point.