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Role of Not proteins in the DNA damage response. (A) Log phase cultures of wild-type or mutant strains were diluted and spotted on YPD plates with or without 25 or 100 mm HU or 0.02% MMS. not2Δ, not5Δ, and dun1Δ not5Δ strains were grown for 5 days before pictures were taken. All other strains were photographed after 3 days. (B) Survival after prolonged exposure to HU was measured as described for Figure 1B. wt, wild type.
