FIG. 5.

Multiple sequence alignments of conserved regions in functionally different α/β-hydrolase fold enzymes, represented as bit scores for each position, with the total height indicating the degree of conservation (maximum level, 4.32) and the relative heights of different symbols at the same position indicating the frequencies of the amino acids at that position. (A) H-G-X-P region in epoxide hydrolases and haloalkane dehalogenases. (B) Region around the nucleophilic aspartate in epoxide hydrolases and fluoroacetate dehalogenases.