TABLE 5.

Detection of specific microorganisms in saliva of individuals prior to and in the days following dosing with Streptococcus salivarius K12^a

Organism(s)	No. of subjects in which the indicated class of microbe was detected/total no. of subjects at the following sampling time:					Maximum CFU/ml detected in any single sample
	Predosing	Day 3	Day 7	Day 14	Day 28
S. salivarius K12-like BLISc profile	2/14	13/14	12/14	9/14	4/14	NAd
S. salivarius K12-like BLIS profile >50%	2/14	7/14	7/14	3/14	1/14	NA
S. mutansb	9/14	11/14	9/14	11/14	9/13	6.3e5
S. mutans >1e4 CFU/ml	4/14	4/14	4/14	5/14	4/14	NA
S. mutans >1e5 CFU/ml	2/14	2/14	1/14	1/14	1/14	NA
Lactobacilli	6/14	5/14	4/14	7/14	2/14	2.8e5
Candida	1/14	NDe	1/14	1/14	1/14	4.4e4
Coliforms	1/14	2/14	0/14	1/14	0/14	140
Pseudomonas	11/14	8/14	10/14	9/14	5/14	100
Staphylococcus aureus	3/14	4/14	1/14	2/14	2/14	1,000

^aSubjects included 4 males and 10 females; mean age, 19 years.

^bP values for time point differences for S. mutans counts were not significant (>0.5 by nonparametric analysis of variance).

^cBLIS, bacteriocin-like inhibitory substance.

^dNA, not applicable.

^eND, not determined.