Table 3.
Chromosomal localization and clustering of genes with reduced expression in PsA compared with controls.
| Chromosomal band | Downregulated, n (%) | All chip genes, n (%)a | P valueb |
|---|---|---|---|
| 1p36 | 8 (3.11) | 315 (1.63) | 0.06459 |
| 3p21 | 8 (3.11) | 187 (0.97) | 0.0005945d |
| 6p21 | 12 (4.67) | 432 (2.24) | 0.009421d |
| 12p1 | 6 (2.33) | 189 (0.98) | 0.02996c |
| 14q32 | 5 (1.94) | 113 (0.59) | 0.005234d |
| 16p11 | 6 (2.33) | 66 (0.34) | 1.63×10−7d |
| 16p13 | 6 (2.33) | 229 (1.19) | 0.0937 |
| 16q24 | 5 (1.94) | 58 (0.30) | 3.82×10−6d |
| 17p13 | 10 (3.89) | 177 (0.92) | 1.15×10−6d |
| 17q25 | 5 (1.94) | 71 (0.37) | 5.43×10−5d |
| 19p13 | 10 (3.89) | 535 (2.77) | 0.28 |
| 19q13 | 15 (5.84) | 620 (3.21) | 0.01852c |
| 22q13 | 8 (3.11) | 253 (1.31) | 0.01247c |
a
Genes present in the U133A chip with available chromosomal band location (19,286);
b
χ2;
c
P < 0.05;
d
P < 0.01.