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. 2005 Mar;169(3):1553–1571. doi: 10.1534/genetics.104.032367

TABLE 2.

Estimated rates of invasion for all chromosome lines (except the five lines whereTM2 was never seen)

+/+ lethal: invaders λTM2 λTM1 p+/+ Fitness
change		 Viability:
TM2/+
graphic file with name M5.gif
 log(L):
β ≠ 0
1A   1.562 0.466 0.000    0.7131  1.207 0.0045813 −242.24
1B   1.262 0.305 0.000    0.3771  1.927 0.0067693 −262.39
Mean   1.404 0.377 0.000    0.5185  1.525 0.0055688
3A   2.485 0.020 0.000    0.0173  0.710 0.0117574 −148.88
3B   2.550 0.009 0.000    0.0082  0.772 0.0039561 −166.49
Mean   2.517 0.013 0.000    0.0119  0.740 0.0068201
7A   2.332 0.062 0.000    0.0471  1.216 0.0036952  −90.30
7B   2.164 0.056 0.000    0.0416  1.141 0.0046454 −116.10
Mean   2.247 0.059 0.000    0.0443  1.178 0.0041432
8A   1.415 0.721 0.000    0.9737  1.832 0.0067498 −219.18
8B   1.403 0.728 0.000    1.0491  1.804 0.0072812 −187.09
Mean   1.409 0.724 0.000    1.0107  1.818 0.0070105
10A   1.908 0.535 0.000    0.7366  7.942 0.0002799 −175.49
10B   1.357 0.341 0.000    0.4539  5.213 0.0028138 −156.65
Mean   1.609 0.427 0.000    0.5782  6.434 0.0008875
11A   2.043 0.017 0.000    0.0148  0.793 0.0035759 −150.83
11B   2.224 0.056 0.000    0.0563  0.572 0.0013105 −105.77
Mean   2.130 0.030 0.000    0.0288  0.674 0.0021647
14A   1.242 0.268 0.000    0.3259  1.326 0.0116063 −225.27
14B   1.570 0.514 0.000    0.7913  0.903 0.0085580 −294.98
Mean   1.396 0.371 0.000    0.5078  1.094 0.0099662
15A   0.492 0.007 0.000    0.0022  1.861 0.0012382 −128.13
15B   1.752 0.583 0.000    0.8024  1.510 0.0028044 −225.08
Mean   0.846 0.061 0.000    0.0422  1.676 0.0018635
16A   1.459 0.699 0.000    0.9522  1.070 0.0214116 −321.08
16B   1.346 0.584 0.000    0.7708  1.150 0.0244692 −283.92
Mean   1.402 0.639 0.000    0.8567  1.109 0.0228894
21A   1.310 0.619 0.000    0.7943  1.233 0.0090847 −153.15
21B   1.219 0.588 0.000    0.7028  1.266 0.0124318 −240.58
Mean   1.263 0.603 0.000    0.7471  1.249 0.0106273
22A   3.480 0.016 0.000    0.0136  1.623 0.0021089 −134.30
22B   2.756 0.021 0.000    0.0160  1.644 0.0041351 −144.74
Mean   3.097 0.018 0.000    0.0148  1.634 0.0029531
24A   5.713 0.011 0.000    0.0111  0.921 0.0016875 −150.19
24B   5.459 0.015 0.000    0.0144  0.919 0.0019030 −154.02
Mean   5.585 0.013 0.000    0.0126  0.920 0.0017920
26A   2.683 0.023 0.000    0.0198  1.077 0.0054721 −186.57
26B   3.131 0.019 0.000    0.0169  1.048 0.0033614 −196.43
Mean   2.898 0.021 0.000    0.0183  1.062 0.0042888
28A   1.531 0.338 0.000    0.5070 22.432 0.0000635 −193.78
28B   0.518 0.036 0.000    0.0099  1.097 0.0061722 −157.76
Mean   0.752 0.106 0.000    0.0708  4.961 0.0006260
30A   1.457 0.905 0.000    0.8843  1.805 0.0038142 −204.50
30B   1.476 0.901 0.000    1.0205  1.606 0.0040417 −199.68
Mean   1.467 0.903 0.000    0.9499  1.702 0.0039263
Overall
  mean		   1.750 0.118 0.000    0.1195  1.480 0.0038181
+/+ viable: invaders λTM2 λTM1 p+/+ Fitness
change		 Viability:
TM2/+
graphic file with name M6.gif
 log(L):
β ≠ 0
31A   1.779 6.657 0.292    1.9520  3.608 0.0013915 −263.51
31B   1.878 5.818 0.299    2.0191  2.638 0.0010161 −255.82
Mean   1.853 6.331 0.291    1.9853  3.085 0.0011891
34A   1.916 2.374 0.262    0.7060  2.139 0.0007013 −297.24
34B   2.297 2.220 0.273    1.1179  2.119 0.0002342 −255.34
Mean   2.098 2.293 0.267    0.8884  2.129 0.0004053
35A   1.975 1.352 0.466    1.6204  3.854 0.0000960 −341.46
35B   1.501 0.793 0.446    1.2569  2.867 0.0007032 −313.05
Mean   1.698 1.010 0.456    1.4271  3.324 0.0002598
36A   1.985 −276.181 0.377    1.9795  2.736 0.0001700 −210.91
36B   1.950 4.385 0.374    1.5399  3.163 0.0001038 −174.88
Mean   1.733 5.061 0.375    1.7459  2.942 0.0001329
Overall
  mean		   1.839 2.935 0.340    1.4479  2.831 0.0003591
2A   6.680 — 0.000   73.9226  2.494 0.973 1.484  0.000 0.0000212
2B   8.366 — 0.000  118.1310  3.279 1.558 1.422  0.000 6.9746296 × 10−6
Mean   7.476 — 0.000   93.4481  2.860 1.231 1.453  0.000 0.0000122
4A   5.342 — 0.000  158.7150  1.679 0.824 1.017  0.000 0.0000512
4B   4.363 — 0.000  111.6680  1.598 2.481 2.915  0.000 0.0001559
Mean   4.634 — 0.000  133.1300  1.638 1.430 1.722  0.000 0.0000894
6A  27.144 — 0.000 3440.4400  2.372 0.899 1.135  0.000 1.1457538 × 10−8
6B  15.535 — 0.000  612.0740  2.157 1.242 1.267  0.000 6.7685416 × 10−8
Mean  20.500 — 0.000 1451.1400  2.262 1.057 1.199  0.000 2.7847949 × 10−8
9A  12.232 — 0.000  103.3320  1.607 1.097 1.090  0.000 7.6574317 × 10−9
9B   8.821 — 0.000   57.6355  1.720 1.284 1.220  0.000 9.2701874 × 10−8
Mean  10.129 — 0.000   77.1725  1.663 1.187 1.153  0.000 2.6643166 × 10−8
18A   7.092 — 0.000  452.8530  1.949 1.042 1.689  0.000 0.0002965
18B   5.613 — 0.000   69.7364  2.082 0.959 1.243  0.000 0.0002335
Mean   6.306 — 0.000  177.7080  2.014 1.000 1.449  0.000 0.0002631
19A   5.421 — 0.000   74.8200  1.447 1.050 1.315  0.000 0.0000224
19B   7.370 — 0.000  102.0140  3.577 0.952 1.155  0.000 4.6468098 × 10−6
Mean   5.982 — 0.000   87.3651  2.275 1.000 1.232  0.000 0.0000102
20A  20.739 — 0.000  280.8350  1.489 0.933 1.174  0.000 5.1929305 × 10−10
20B  31.345 — 0.000 1078.0700  1.305 1.124 1.149  0.000 2.6148143 × 10−10
Mean  25.319 — 0.000  550.2350  1.394 1.024 1.161  0.000 3.6849083 × 10−10
25A  10.899 — 0.000 2463.2800  4.878 1.889 2.155  0.000 8.4657158 × 10−6
25B  11.303 — 0.000  481.8910  3.037 1.016 1.045  0.000 4.3325064 × 10−6
Mean  10.121 — 0.000 1089.5100  3.849 1.385 1.501  0.000 6.0562173 × 10−6
27A  35.637 — 0.000  754.3600  2.296 1.110 1.466  0.000 9.0582531 × 10−12
27B  19.012 — 0.000  277.6880  1.721 1.009 1.350  0.000 7.6131214 × 10−10
Mean  26.017 — 0.000  457.6860  1.988 1.058 1.407  0.000 8.3043110 × 10−11
29A   3.927 — 0.000  153.5120  2.134 1.140 1.406  0.000 0.0001815
29B   2.705 — 0.000   29.0622  2.208 1.038 1.478  0.000 0.0003850
Mean   3.256 — 0.000   66.7938  2.171 1.088 1.442  0.000 0.0002643
Overall
  mean		   9.485 — 0.000  228.9890  2.124 1.137 1.361  0.000 7.9898344 × 10−7
Viability
Viability (Gardner …et al. 2001)
+/+ viable: transient λTM2 λTM1 p+/+ Fitness
change		 TM2/+ TM1/+ TM2/+ +/+
graphic file with name M7.gif
 log(L):
β ≠ 0
32A 367.497 — 0.750 1569.8300  1.648 7.097 6.886 14.103 3.7305272 × 10−24 −106.51
32B 107.425 — 0.745  236.5090  2.365 5.122 7.125 21.902 1.0861418 × 10−20  −86.99
Mean 197.042 — 0.747  609.3260  1.974 6.029 7.004 17.575 2.0129286 × 10−22
33A   1.605 — 0.449    1.8427  2.709 1.234 1.028  1.094 0.0004253 −143.25
33B   1.368 — 0.449    1.3204  2.042 1.056 1.113  0.838 0.0007230 −153.99
Mean   1.513 — 0.441    1.5598  2.352 1.142 1.070  0.957 0.0005545
37A   3.880 — 0.627    4.5437  1.570 2.462 2.163  2.505 2.3852962 × 10−7  −74.80
37B   5.011 — 0.629    6.6908  1.361 1.730 2.710  2.256 4.0890481 × 10−8  −78.15
Mean   4.123 — 0.621    5.5137  1.462 2.064 2.421  2.377 9.8760269 × 10−8
38A   4.706 — 0.656    4.9252  1.540 3.958 4.850  9.137 1.6082468 × 10−8  −70.61
38B   4.278 — 0.657    2.7922  1.123 4.233 3.843  6.315 6.8179905 × 10−9  −89.67
Mean   4.597 — 0.641    3.7084  1.315 4.093 4.317  7.596 1.0471395 × 10−8
39A   4.595 — 0.516   12.7204  2.042 2.352 3.411  4.842 1.4723967 × 10−6 −124.24
39B   2.678 — 0.517    5.2098  1.813 3.681 4.126  9.270 0.0000420 −130.55
Mean   3.431 — 0.505    8.1407  1.924 2.942 3.752  6.700 7.8611853 × 10−6
40A   6.098 — 0.556   28.6477  1.597 1.892 3.767  0.091 2.2080807 × 10−6 −112.51
40B  29.501 — 0.562  469.1670  1.740 2.483 6.867  0.201 8.4661374 × 10−11  −70.32
Mean  12.764 — 0.537  115.9330  1.667 2.167 5.086  0.135 1.3672569 × 10−8
Overall
  mean		   7.923 — 0.573   16.2395  1.749 2.680 3.381  2.551 1.5215358 × 10−9
41A 1.243 0.306 0.000    0.1750  1.222 0.0013800 −393.25
41B 1.134 0.124 0.000    0.0618  1.902 0.0012016 −381.77
Mean 1.187 0.195 0.000    0.1040  1.524 0.0012877
42A 1.715 0.910 0.000    0.6938  2.152 0.0009722 −407.62
42B 1.717 0.748 0.000    0.6043  3.114 0.0007891 −696.58
Mean 1.716 0.825 0.000    0.6475  2.589 0.0008759
43A 2.360 0.826 0.000    1.9087  1.607 0.0008832 −383.60
43B 1.751 0.497 0.000    0.3527  1.409 0.0007775 −335.69
Mean 1.733 0.550 0.000    0.8205  1.505 0.0008286
44A 1.957 0.857 0.000    0.6219  2.704 0.0005816 −517.08
44B 1.676 0.608 0.000    0.4910  1.850 0.0011418 −351.15
Mean 1.798 0.720 0.000    0.5526  2.237 0.0008149
45A 5.623 0.771 0.000    1.3375  0.974 0.0009409 −939.64
45B 10.858 0.775 0.000    1.0685  1.224 0.0006243 −614.89
Mean 7.803 0.761 0.000    1.1954  1.092 0.0007665
46A 1.727 0.876 0.000    1.4813  1.736 0.0020647 −489.17
46B 1.747 0.902 0.000    0.8474  1.760 0.0015409 −356.02
Mean 1.636 0.822 0.000    1.1204  1.748 0.0017837
47A 2.349 1.210 0.000    2.7815  1.300 0.0018167 −865.37
47B 1.542 0.667 0.000    0.5374  1.602 0.0022558 −356.40
Mean 1.706 0.811 0.000    1.2226  1.443 0.0020244
48A 2.046 0.775 0.000    0.4475  1.666 0.0002684 −342.07
48B 1.441 0.561 0.000    0.4332  2.038 0.0018115 −491.06
Mean 1.704 0.659 0.000    0.4403  1.843 0.0006973
49A 1.118 0.338 0.000    0.1782  1.678 0.0010559 −430.84
49B 2.201 0.933 0.000    0.6009  1.740 0.0000793 −319.93
Mean 1.560 0.559 0.000    0.3272  1.708 0.0002893
50A 0.964 0.182 0.000    0.0912  2.396 0.0020273 −316.74
50B 1.199 0.222 0.000    0.1299  1.844 0.0007821 −400.94
Mean 1.075 0.201 0.000    0.1088  2.102 0.0012592
51A 1.484 0.711 0.000    0.5311  2.061 0.0009998 −343.73
51B 1.441 0.699 0.000    0.5382  1.563 0.0011005 −239.96
Mean 1.462 0.705 0.000    0.5347  1.795 0.0010489
Overall
  mean		 1.783 0.560 0.000    0.4931  1.737 0.0009489
Fowler …et al. (1997)
+/+ lethal:
transient		 λTM2 λTM1 p+/+ Fitness
change		 Viability:
TM2/+
graphic file with name M8.gif
 log(L):
β ≠ 0
52A 0.823 1.655 0.000    0.4906  1.500 0.0003453  −69.55
52B 0.660 0.204 0.000    0.0497  1.832 0.0003065 −121.76
Mean 0.737 0.580 0.000    0.1562  1.658 0.0003253

Columns 2 and 3 show the estimated rates of invasion of TM2 and rate of elimination of TM1 per day (λTM2, λTM1). Column 4 shows the estimated frequency of wild-type homozygotes in adult samples (p+/+). Column 5 shows the factor by which fitness is estimated to change through the experiment (as in Table S1, supplementary information at http://www.genetics.org/supplemental/). Column 6 gives the viability of TM2/+ relative to TM1/TM2 in sample vials. For those chromosomes in which TM2 appeared transiently, the viability estimates of Gardner et al. (2001) are given; these are shown in Table S1 for the other lines. The penultimate column shows the ratio between initial TM2 frequency and the viability of TM1/+ relative to TM1/TM2, p0/VTM1/+. The final column shows the log likelihood of the fit, assuming varying fitnesses (β ≠ 0, as in Table S1); this is a measure of the unexplained residual variation.