TABLE 2.

Functional comparison ofC. elegans andC. briggsae orthologs

C. elegans ortholog	A/Xa	Phenotypeb	C. briggsae ortholog	Phenotypec (n)
rpl-11.1	A	Sterile	CBG01314	Sterile (7/7)
rpl-11.2	X	Fertile (Gro)	CBG14053	Sterile (1/8), sub-Fertiled (7/8)
Progeny: Lva/Gro
rpl-24.1	A	Fertile (Gro)	CBG22273	Sterile (2/8), sub-Fertiled (6/8)
Progeny: Lva/Gro
rpl-24.2	A	Fertile (Gro)	CBG03702	sub-Fertiled (7/7)
Progeny: Lva/Gro
rpl-25.1	X	Fertile (WT)	CBG14529	Fertilee (5/5)
Progeny: WT
rpl-25.2	A	Sterile	CBG04080	Sterile (3/3)
pab-1	A	Sterile	CBG02207	Sterile (8/8)
pab-2	X	Fertile (WT)	CBG07431	sub-Fertiled (7/7)
Progeny: WT/Gro
L4440 (−)ctrl	Fertile (5/5)f
				Progeny: WT

Lva, larval arrest.

^aAutosome or X-linked locus in C. elegans; Gro, growth defect.

^bSummarized from Table 1 and from the text. Phenotype refers to progeny phenotype from RNAi feeding experiments (see materials and methods).

^cPhenotype of injected animals (n, number of animals displaying phenotype per number of surviving injected animals) as assessed after overnight transfer to deplete animals of embryos produced prior to the injection (see materials and methods). In addition, few of the adult progeny produced by these fertile injected animals exhibited sterility compared to a high penetrance of sterility observed in the progeny (first 12 hr) from injected animals that quickly became sterile.

^dThese animals were subfertile, producing few embryos, some embryonic lethality, and few live progeny: CBG14053, average <4 surviving progeny per injected animal; CBG22273 and CBG03702, average <2 surviving progeny per injected animal; CBG07431, average <5 surviving progeny per injected animal.

^eThese animals were fertile, producing many embryos but few live progeny due to embryonic lethality: CBG14529, average <2 surviving progeny per injected animal.

^fNegative control (see materials and methods), ≥20 progeny per injected animal over 2–3 days scored.