E-DNA: A reagentless, reusable means for the electrochemical detection of unpurified PCR amplicons. Shown are baseline-subtracted AC voltammograms from the E-DNA sensor before use, after incubation with PCR products containing the relevant 17-base recognition element at their 3′-end (illustrated in Inset), and after regeneration via a simple, room temperature rinse with distilled water. Of note, these data were collected directly in the PCR buffer without any purification of the PCR products.