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. 2006 Mar 2;103(11):4140–4145. doi: 10.1073/pnas.0508881103

Fig. 2.

Fig. 2.

Hypoplasia of the reproductive organs in Pkr2−/− mice. (A) Macroscopic view of the testes at 8 weeks of age from the control wild-type littermates and Pkr1−/− mice (Left), control wild-type littermates and Pkr2−/− mice (Center), and the ovary and uterus (Right) at 12 weeks of age from the wild-type, Pkr1−/−, and Pkr2−/− mice. The male and female reproductive organs are small in the Pkr2−/− mice. (Scale bars, 5 mm.) (B) HE-stained sections of wild-type and Pkr2−/− testis at 20 weeks of age. Higher magnification (rectangle) shows normal Leydig cells in wild-type testis (Lower Left), whereas the mutant testis shows small Leydig cells and no spermatid (Lower Right). SPG, spermatogenic cell; SPC, spermatocytes; SPT, spermatid; LC, Leydig cells. [Scale bars, 100 μm (Upper) and 10 μm (Lower).] (C) HE-stained sections of wild-type and Pkr2−/− ovary at 20 weeks of age. A magnified region (rectangle) shows normal antral follicle (arrow) in wild-type ovary (Lower Left). A magnified region (rectangle) shows undeveloped follicles (arrows) in Pkr2−/− ovary (Lower Right). [Scale bars, 200 μm (Upper) and 50 μm (Lower).]