Fig. 2.
Regression of LVH with CNTF in ob/ob and db/db mice. (a–g) M-mode echocardiograms after 4 weeks after intervention of 5–6 months old ob/ob mice fed ad libitum (a), treated with CNTFAx15 (b), or calorie-restricted (c) and db/db mice fed ad libitum (d), treated with CNTFAx15 (e), calorie restricted (f), and treated with leptin (g). Notable findings include reduction in both septal and posterior wall thickness in the CNTFAx15-treated animals compared with other groups. (h and i) Graphical demonstration of significant decreases in posterior wall thickness in diastole (PWTd) in ob/ob mice (h; ∗, P = 0.000022) and db/db mice (i; ∗, P = 0.029; †, P = 0.00019) with CNTFAx15 treatment. AL, ad libitum; LEP, leptin; CR, calorie restriction. Arrows denote endo- and epicardial borders of heart wall.