Fig. 3.
CNTFAx15 mediated reduction of myocyte width in ob/ob and db/db mice. (a–g) Histology sections stained with hematoxylin/eosin from ob/ob mice fed ad libitum (a), treated with CNTFAx15 (b), or calorie-restricted (c) and db/db mice fed ad libitum (d), treated with CNTFAx15 (e), calorie-restricted (f), and treated with leptin (g). (h and i) Graphical demonstration that myocytes from CNTFAx15-treated ob/ob (h) and db/db (i) mice have decreased cell width compared to the control groups (∗, P < 0.0001). AL, ad libitum; LEP, leptin; CR, calorie restriction. (Scale bar: 5 microns.) Arrows denote borders of cardiac myocytes.