Fig. 6.
Impact of CNTFAx15 on ERK and JNK signal transduction pathways in ob/ob and db/db mice. (a and b) Western blot analysis depicts increased ERK phosphorylation and ERK protein expression in cardiac tissue of ob/ob (filled bars) and db/db mice (hatched bars) with CNTFAx15 (CNTF) treatment but not with leptin (LEP) in db/db mice. (c and d) CNTFAx15 increased JNK protein abundance in heart tissue in ob/ob and db/db mice. However, calorie restriction (CR) does not affect JNK protein expression in cardiac tissue of ob/ob and db/db mice. (∗, P < 0.05.)