Table 1.

Baseline body weights and echocardiographic parameters in WT, ob/ob, and db/db mice prior to the start of intervention

Parameter	WT	ob/ob	db/db
No. of mice	15	31	30
Age, months	5	5–6	5–6
BW, g	22 ± 0	70 ± 1*	59 ± 1*,†
IVSd, mm	0.76 ± 0.03	1.10 ± 0.02*	1.03 ± 0.03*
PWTd, mm	0.85 ± 0.02	1.03 ± 0.02*	0.96 ± 0.02*
LVEDd, mm	3.26 ± 0.10	3.51 ± 0.07	3.59 ± 0.07‡
LVEDs, mm	1.63 ± 0.06	1.51 ± 0.07	1.51 ± 0.07
LVM, mg	87 ± 6	143 ± 4*	138 ± 5*

BW, body weight; IVSd, interventricular septal thickness in diastole; PWTd, posterior wall thickness in diastole; LVEDd, left ventricular end-diastolic diameter; LVEDs, left ventricular end-systolic diameter.

*, P < 0.01 vs. WT;

†, P < 0.01 vs. ob/ob; and

‡, P < 0.05 vs. WT by one-way ANOVA.