Table 2.
Changes in echocardiographic parameters after intervention in ob/ob mice
| Parameter | Fed ad libitum (n = 11) |
CNTFA×15-treated (n = 11) |
Calorie-restricted (n = 9) |
|||
|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | |
| BW, g | 70 ± 1 | 72 ± 1 | 70 ± 2 | 43 ± 2* | 71 ± 2 | 46 ± 2* |
| IVSd, mm | 1.11 ± 0.04 | 1.15 ± 0.04 | 1.13 ± 0.04 | 0.90 ± 0.03* | 1.05 ± 0.04 | 0.95 ± 0.04 |
| PWTd, mm | 1.02 ± 0.03 | 1.12 ± 0.03 | 1.10 ± 0.03 | 0.86 ± 0.03* | 0.97 ± 0.02 | 0.90 ± 0.04 |
| LVEDd, mm | 3.60 ± 0.14 | 3.29 ± 0.10 | 3.38 ± 0.09 | 3.20 ± 0.09 | 3.56 ± 0.16 | 3.22 ± 0.08 |
| LVEDs, mm | 1.49 ± 0.10 | 1.19 ± 0.06† | 1.50 ± 0.11 | 1.12 ± 0.03† | 1.54 ± 0.15 | 1.23 ± 0.05† |
| LVM, mg | 149 ± 7 | 144 ± 6 | 147 ± 10 | 106 ± 14* | 135 ± 5 | 100 ± 5* |
*, P < 0.01 vs. preintervention baseline and
†, P < 0.05 vs. preintervention baseline by paired t tests. Abbreviations are as per Table 1.