Table 3.
Changes in echocardiographic parameters after intervention in db/db mice
| Parameter | Fed ad libitum (n = 7) |
CNTFA×15-treated (n = 8) |
Calorie-restricted (n = 8) |
Leptin-treated (n = 7) |
||||
|---|---|---|---|---|---|---|---|---|
| Before | After | Before | After | Before | After | Before | After | |
| BW, g | 59 ± 1 | 62 ± 2 | 60 ± 2 | 43 ± 1* | 60 ± 2 | 41 ± 1* | 58 ± 2 | 61 ± 2 |
| IVSd, mm | 0.94 ± 0.06 | 1.08 ± 0.06 | 1.11 ± 0.07 | 0.79 ± 0.05* | 1.02 ± 0.02 | 0.93 ± 0.06 | 1.05 ± 0.06 | 1.11 ± 0.02 |
| PWTd, mm | 0.90 ± 0.04 | 1.04 ± 0.05† | 1.02 ± 0.02 | 0.80 ± 0.04* | 0.94 ± 0.02 | 0.94 ± 0.05 | 1.02 ± 0.04 | 1.08 ± 1.02 |
| LVEDd, mm | 3.29 ± 0.17 | 3.33 ± 0.15 | 3.65 ± 0.13 | 3.31 ± 0.08* | 3.80 ± 0.12 | 3.22 ± 0.08* | 3.56 ± 0.12 | 3.31 ± 0.08 |
| LVEDs, mm | 1.21 ± 0.11 | 1.09 ± 0.18 | 1.50 ± 0.13 | 1.20 ± 0.02† | 1.72 ± 0.14 | 1.25 ± 0.05† | 1.53 ± 0.06 | 1.23 ± 0.04* |
| LVM, mg | 107 ± 11 | 135 ± 6 | 150 ± 7 | 87 ± 8* | 148 ± 7 | 103 ± 8* | 143 ± 5 | 137 ± 4 |
*, P < 0.01 vs. preintervention baseline and
†, P < 0.05 vs. preintervention baseline by paired t tests. Abbreviations are as per Table 1.