TABLE 4.
MMR-deficient mutation spectra in different species
| Genotype | BS/ID | Ts/Tv | Ins/Del |
|---|---|---|---|
| Ce WT (76 loci) | 13/17 | 8/5 | 13/4 |
| Ce msh-2 (24 loci) | 11/6 | 8/3 | 3/3 |
| Ce msh-6 (23 loci) | 9/3 | 7/2 | 1/2 |
| Ce msh-6 (ZK337) | 0/7 | 0/0 | 7/0 |
| Sc msh2 (Canr) | 3/17 | 0/3 | 1/16 |
| Sc msh6 (Canr) | 18/3 | 12/6 | 0/3 |
| Sc msh3 msh6 (Canr) | 7/15 | 3/4 | 1/14 |
| Hs msh2 (hprt) | 16/4 | 16/0 | 0/4 |
| Hs msh3 (hprt) | 38/32 | 37/1 | 8/24 |
| Hs msh6 (hprt) | 59/3 | 20/39 | 2/1 |
Genotype refers to the species (Ce, C. elegans; Sc, S. serevisiae; Hs, Homo sapiens; Mm, Mus musculus) and specific MMR-deficient genetic background for which mutation data were reported. The specific loci assayed are listed in parentheses. BS/ID indicates the observed ratio of base substitution to indel mutations, Ts/Tv refers to the ratio of transitions to transversions, and Ins/Del indicates the ratio of insertions to deletions (excludes HP loci ≥ 8 bp). The WT C. elegans data are from Denver et al. (2004b); the S. cerevisiae data are from Marsischky et al. (1996); and H. sapiens data are from Malkhosyan et al. (1996), Ohzeki et al. (1997), Tauchi et al. (2000), and Mark et al. (2002). The data for msh-6 C. elegans are divided into two sets to distinguish between patterns observed at the majority of loci vs. the ZK337 hotspot locus.