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Schematic of histidine and IMP biosynthesis pathways and reactions supplying 10 formyl-THF for IMP biosynthesis. FGAR, 5′-phosphoribosyl N-formylglycinamide; IMP, inosine 5′-monophosphate; PRPP, 5-phosphoribosyl-1-pyrophosphate; SAMP, adenylosuccinate; XMP, xanthosine 5′-monophosphate. Gene names are italicized. For simplicity, only intermediate metabolites that are cited in the text are indicated.
