Schematic of connections among histidine, purine, folate, and methionine metabolism in yeast. Gene names are italicized. CH + THF, methenyl-tetrahydrofolate; 5-CHO-THF, 5-formyl-tetrahydrofolate; CH2-THF, methylene-tetrahydrofolate; CH3-THF, methyl-tetrahydrofolate.