Figure 4.—

(A) Allele-frequency comparison between the Japanese and a reference panel. The minor allele was set as the less-frequent allele in the combined population, and MAF was calculated in each population for the 979 SNPs analyzed. (B) Correlation coefficients of MAFs according to the positional classes of SNPs. MAFs of SNPs did not show significant correlations between the Japanese and a reference panel and there were no significant differences in correlations among three positional classes of SNPs. (C) Allele-frequency differences between the Japanese and a reference panel. Almost normal distribution was observed in terms of skewness (b₁ = −0.04) but not in terms of kurtosis (b₂ = 0.50, significantly different from normal distribution).