TABLE 1.

SNPs genotyped in theLPL gene

					Minor allele frequency (%)d					Previously studied SNPs in LPLe
Namea	In gene	SNPb	Amino Acidc	nt position (chromosome 8) RefSeq Build 34	Japanese	African Americans	Caucasians	dbSNP ID	JSNP ID	Templeton et al. (2000a)	Morabia et al. (2003)
SNP1f,g	Intron 1	G/A	—	19,809,412	0.0	11.2	23.2	—	—	—	—
SNP2f	Intron 1	C/T	—	19,812,675	88.5	18.5	52.0	rs10104051	—	—	—
SNP3	Intron 3	C/A	—	19,821,060	10.6	5.9	6.6	rs343	—	1	—
SNP4f	Exon 4	G/A	I/I	19,821,099	0.0	4.5	7.5	rs248	—	3	Exon 4_b.6
SNP5	Intron 4	T/C	—	19,821,279	6.3	10.2	9.6	rs249	—	4	—
SNP6	Intron 5	C/G	—	19,822,170	16.4	20.4	14.4	rs254	—	9	—
SNP7	Intron 6	T/G	—	19,823,940	18.5	41.6	17.4	rs269	IMS-JST003328	19	Exon 6_+73
SNP8	Intron 6	C/A	—	19,823,949	6.3	9.9	20.4	rs270	—	20	Exon 6_+82
SNP9	Intron 6	T/C	—	19,826,644	18.3	34.4	23.2	rs297	—	43
SNP10	Intron 7	T/C	—	19,827,207	15.0	33.0	23.5	rs301	IMS-JST185262	44	—
SNP11	Intron 7	G/C	—	19,828,270	7.7	27.3	11.2	rs312	—	51
SNP12	Exon 8	C/A	T/T	19,828,709	6.3	24.7	11.2	rs316	—	55	Exon 8_b.25
SNP13f	Intron 8	A/G	—	19,829,712	18.5	58.0	30.3	rs326	IMS-JST089898	65	—
SNP14	Intron 8	T/G	—	19,829,809	15.6	46.3	29.2	rs327	IMS-JST089899	66	Exon 9_-90
SNP15	Exon 9	C/G	S/X	19,829,997	9.6	7.2	9.2	rs328	IMS-JST089900	—	Exon 9_b.99
SNP16	Intron 9	C/T	—	19,833,083	9.5	7.7	10.5	rs11570891	—	—	Exon 10_-11
SNP17	Exon 10	G/A	—	19,833,103	6.3	13.8	16.0	rs4922115	—	—	Exon 10_b.10
SNP18	Exon 10	A/G	—	19,833,890	5.8	29.3	15.7	rs11570892	—	—	—
SNP19	Exon 10	A/T	—	19,833,921	14.7	55.6	28.6	rs3208305	—	—	—
SNP20	Exon 10	C/T	—	19,834,236	6.2	12.1	13.5	rs1059507	IMS-JST089901	—	—
SNP21	Exon 10	C/A	—	19,834,318	9.4	7.1	10.7	rs3735964	IMS-JST089902	—	—
SNP22	Exon 10	T/C	—	19,834,765	15.5	53.2	29.1	rs13702	—	—	—
SNP23	Exon 10	C/A	—	19,834,942	6.6	22.0	16.0	rs3866471	—	—	—
SNP24	3′-flanking	T/G	—	19,835,169	22.3	8.0	29.0	rs9644636	—	—	—
SNP25f	3′-flanking	C/T	—	19,841,194	10.9	44.4	12.0	rs10096633	—	—	—

^aThe number of an SNP corresponds with the location order in the LPL gene. Among them, SNP1 and SNP4 were not informative in the Japanese.

^bThe nucleotide to the left of the slash was the more frequent allele.

^cX denotes a stop codon.

^dIndividual SNPs were characterized in 113 Japanese, 100 African Americans, and 100 Caucasians as described in materials and methods.

^eWhen applicable, the identity of SNPs previously studied by two other groups of researchers is shown for the relevant SNPs characterized in this study.

^fSNPs derived from Assays-on-Demand (Applied Biosystems).

^gAssays-on-Demand ID was C_9642874_10.