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MRI of the high-dose long-term animal. MRI scans were performed to ascertain the course of (a) Baseline MRI displayed normal brain structure and appearance. (b) At 4 days postinjection of 1 × 109 PFU NUREL-C2, MRI revealed an apparent inflammatory response in the same circular pattern as vector injection. The inflammatory response was reduced after 2-weeks (c) and resolved by 4 weeks (d) postinjection when the brain returned to normal appearance.
