Figure 3.—

lola interacts genetically with cut during wing-margin development. (A–H) The overexpression of lola^GS[A916] can suppress the wing phenotype of ct^K (B), ct⁶ (D), ct^53d (F), and ct^2s (H); compare to UAS-lacZ negative control wings (A, C, E, and G). Solid arrowheads in A represent discontinuities in the anterior wing margin; open arrowheads in D, F, and H represent rescue of margin tissues. (I and J) Loss-of-function lola alleles enhance sensory bristle loss in the anterior wing margin of ct^53d. (I) A single copy of the amorphic lola^ORE76 allele aggravates the ct^53d wing phenotype (compare to E). (J) Penetrance of ct^53d-associated gaps in the sensory bristles of the anterior margin of wings heterozygous for various lola alleles. lola^EY8332 and lola^EY10040 are gain-of-function insertions of the EPgy2 P element; lola^KG09113 is a loss-of-function insertion of the suppressor P element; lola^5D2, lola^ORE76, and lola^ORE120 are amorphic alleles; and lola^ORE119 and lola^ORC4 are decision-selective alleles.