Figure 1. Alignment of the ErbB4 potential ligand-binding domain with the corresponding region in EGFR, ErbB2 and ErbB3.

Indicated in boldface, underlined type are the amino acids in ErbB4 that are being implicated in NRG2β binding. The corresponding amino acids of EGFR, ErbB2 and ErbB3 are indicated by boldface, underlined type. Also shown is the relative affinity of NRG2β for each receptor.