Figure 6. The S442F mutation in EGFR appears to create a hydrophobic bulge in the EGFR ligand-binding domain.

(A) The structure of a portion of the extracellular domain of EGFR-Wt is depicted. (B) A computer-generated model of a portion of the extracellular domain of the EGFR-S442F mutant is depicted. For both images, the area surrounding Ser⁴⁴² or Phe⁴⁴² is depicted. Green indicates a hydrophobic surface and purple indicates areas of electron lone pairs capable of hydrogen bonding. Residues are numbered as follows: (1) Val⁴⁴¹; (2) Ser⁴⁶⁴; (3) Gly⁴⁶⁵; (4) Ile⁴⁶²; (5) Ser⁴⁴²; and (6) Phe⁴⁴².