TABLE IV.

Relation between number of positive skin tests and arginase genotypes

SNP	# copies of minor allele	# of cases	# positive skin tests (mean)	OR* (95% CI)	P value for linkage and association†
ARG1
s1	0	109	4.96	1.00
	1	194	5.77	1.34(1.05–1.71)
	2	97	6.72	1.80(1.10–2.92)	0.017
s2	0	110	4.96	1.00
	1	194	5.77	1.35(1.05–1.72)
	2	96	6.75	1.81(1.11–2.95)	0.016
s3	0	121	6.47	1.00
	1	194	5.72	0.75(0.59–0.95)
	2	85	4.95	0.56(0.34–0.91)	0.018
s4	0	151	5.32	1.00
	1	203	5.91	1.42(1.09–1.85)
	2	46	6.76	2.02(1.20–3.41)	0.007
ARG2
s1	0	153	6.10	1.00
	1	166	5.42	0.89(0.69–1.14)
	2	73	5.86	0.78(0.47–1.29)	0.343
s2	0	167	6.07	1.00
	1	156	5.46	0.86(0.67–1.11)
	2	69	5.72	0.75(0.45–1.23)	0.245
s3	0	171	5.63	1.00
	1	176	6.16	0.94(0.74–1.20)
	2	45	4.73	0.88(0.54–1.43)	0.612
s4	0	277	5.51	1.00
	1	111	6.48	1.48(1.04–2.10)
	2	4	4.00	2.18(1.08–4.41)	0.027

CI, confidence interval

^*The odds ratio (OR) is interpreted as the change in odds of inheriting one or two copies of the variant allele per 5 unit change in the number of positive skin tests.

^†P values and odds ratios are based on the additive genetic model