Table 1.
Contacts between Ac-AChBP and α-conotoxins
| Ac-AChBP | Conotoxin PnIA(A10L D14K) | Conotoxin ImI |
|---|---|---|
| Principal side | ||
| Tyr-91* | Arg-7 | |
| Ser-144 | Arg-7 | |
| Trp-145 | Pro-7 | Arg-7, Pro-6 |
| Val-146 | Asn-11 | Arg-7 |
| Tyr-147 | Arg-7 | |
| Tyr-186 | Gly-1, Cys-2, Leu-5 | Gly-1, Cys-2, Asp-5 |
| Cys-188 | Cys-2, Tyr-15 | Cys-2 |
| Cys-189 | Asn-12 | Arg-11 |
| Glu-191 | Asn-12 | Arg-11 |
| Tyr-193 | Cys-8 | Arg-7, Cys-8 |
| Ile-194* | Arg-7 | |
| Complementary side | ||
| Tyr-53 | Ser-4, Pro-6 | — |
| Gln-55* | Cys-3 | |
| Arg-57 | Pro-13 | Cys-12 |
| Asp-75* | Trp-10 | |
| Arg-77 | Asn-11 | Trp-10 |
| Val-106 | Leu-10 | Trp-10 |
| Thr-108* | Trp-10 | |
| Met-114 | Ala-9, Leu-10, Pro-13 | Trp-10, Ala-9 |
| Ile-116 | Ala-9, Leu-10, Pro-13 | Pro-6, Ala-9 |
| Asp-162 | Ser-4 | Ser-4 |
| Ser-164 | Gly-1 | Ser-4 |
H-bonds (2.6–3.4 Å) are shown in bold, a salt bridge is in italics, and van der Waals interactions (3.2–3.8 Å) are in normal font.
*Unique contacts only observed at the Ac-AChBP–ImI interface.