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. 2006 Feb 24;103(10):3740–3745. doi: 10.1073/pnas.0600205103

Fig. 1.

Fig. 1.

OX40–OX40L interactions are required for Th2 differentiation. Naïve CD4 T cells from wild-type (filled circles) or OX40-deficient (open circles) OT-II mice were cultured with APCs and indicated doses of OVA-323–339. (A) IL-4 and IFN-γ recall responses measured at day 7 after Ag/APC restimulation of equal numbers of effector T cells for 24 h. (B) OX40 and OX40L expression on wild-type CD4 and CD11b+CD11c+ APCs after stimulation with 0.1 μM Ag for 36 h. The blank histograms indicate isotype control. The shaded histograms indicate positive staining. (C) Effect of OX40L blocking on recall cytokine responses of wild-type T cells cultured with 0.1 μM Ag. αOX40L, anti-OX40L Ab. All data are representative of at least three individual experiments.