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. 2006 Mar 14;103(12):4344–4351. doi: 10.1073/pnas.0600084103

Fig. 6.

Fig. 6.

SynGAP enhances P38 signaling. (A) Neurons were either blocked or activated as above, except that the stimulation duration was increased to 10 min. Neurons were then immunolabeled with phospho-P38 (p-P38) and microtubule-associated protein 2 (MAP2) antibodies. (B) Quantification of phospho-P38 signal [average pixel intensity (API)] in neurons. ∗∗∗, P < 0.001. (C) Quantification of data (average pixel intensity) from phosphorylated P38 labeling of neurons derived from WT or SynGAP KO mice. Open bars, blocked; filled bars, activated. ∗, P < 0.01. (D) Quantification of phosphorylated P38 immunofluorescence from either blocked or activated neurons expressing eGFP, GFP-SynGAP, GFP-SynGAP_AL (GAP**), or siRNA (si_PAN) constructs. The intensity of transfected neurons was normalized to untransfected neighboring neurons. ∗∗∗, P < 0.001.