Table 3.
Known GroEL substrate proteins
| Protein | Swiss-Prot ID | PDB* | Organism | NB† | NM‡ | NO§ |
|---|---|---|---|---|---|---|
| Rubisco | RBL2_RHORU | 5RUB | Rhodospirillum rubrum | 11 | 0 | 0 |
| Bacterial luciferase α-chain | LUXA_VIBHA | 1LUC | Vibrio harveyi | 8 | 0 | 0 |
| Bacterial luciferase β-chain | LUXB_VIBHA | 1LUC | Vibrio harveyi | 4 | 0 | 0 |
| mMDH | MDHM_PIG | 1MLD | Sus scrofa | 6 | 0 | 0 |
| cMDH | MDHC_PIG | 5MDH | Sus scrofa | 6 | 1 | 0 |
| Subtilisin BPN′ precursor | SUBT_BACAM | 1GNS | Bacillus amyloliquefaciens | 4 | 0 | 0 |
| Barnase | RNBR_BACAM | 1A2P | Bacillus amyloliquefaciens | 2 | 0 | 0 |
| Dihydrofolate reductase | DYR_CHICK | 8DFR | Gallus gallus | 4 | 0 | 0 |
| Lysozyme C precursor | LYSC_CHICK | 1H87 | Gallus gallus | 3 | 0 | 0 |
| Rhodanese | THTR_BOVIN | 1BOI | Bos taurus | 6 | 0 | 0 |
| α-Lactalbumin precursor | LALBA_HUMAN | 1B9O | Homo sapiens | 5 | 1 | 1¶ |
| α-Lactalbumin precursor | LALBA_BOVIN | 1F6R | Bos taurus | 5 | 0 | 0‖ |
*Protein Data Bank ID code of substrate proteins.
†Number of GroES-type SPBM for which the GroEL-accessible area is determined.
‡Number of GroEL-accessible SPBM in monomeric native structures.
§Number of GroEL-accessible SPBM in oligomeric native structures.
¶A single chain is resolved in the crystal structure of the human α-lactalbumin, a heterodimer.
‖Six chains are present in the crystallographic asymmetric unit of the bovine α-lactalbumin, a heterodimer.