Fig. 2.

Liver sections of C3H/HeJ (A–D) and BALB/c (E–H) mice 2 weeks (A–D and G–J) or 3–4 months (E, F, K, and L) after i.v. infusion of Ad-hF.IX (4 × 10¹⁰ particles per mouse). Mice were naïve at the time of adenoviral gene transfer (A, C, E, G, I, and K) or had received hepatic AAV-hF.IX gene transfer 10 weeks earlier (B, D, F, H, J, and L). Immunostaining for hF.IX (red) and CD8 (green) is shown in A, B, E–H, K, and L. Hematoxylin and eosin staining is shown in C, D, I, and J. (Original magnification: ×100.)