Table 2.

Inhibitory effects of GHRH antagonists on the GHRH-induced GH release in vitro in superfused rat pituitary cell system

Antagonist		Inhibition of GH release, %
No.	Code no.	0 min	30 min	60 min	90 min	120 min
Standard antagonist*		52	13	0	0	0
1	MZ-J-7-50	80	87	85	79	69
2	MZ-J-7-52	48	39	44	30	22
3	MZ-J-7-46	95	100	98	92	60
4	MZ-J-7-48	78	80	77	74	73
5	MZ-J-7-42	53	78	88	85	80
6	MZ-J-7-44	85	82	86	76	66
7	MZ-J-7-34	73	69	53	56	60
8	MZ-J-7-38	53	57	34	37	45
9	MZ-J-7-26	40	70	64	65	56
10	MZ-J-7-30	87	84	70	64	65
11	MZ-J-7-18	64	70	65	49	57
12	MZ-J-7-22	13	23	24	29	27
13	MZ-J-7-54	60	32	22	27	39
14	MZ-J-7-56	75	49	32	27	39
15	MZ-J-7-62	79	30	39	24	36
16	MZ-J-7–64	38	36	34	18	26
17	MZ-J-7-102	96	80	63	54	50
18	MZ-J-7-112	58	83	73	56	56
19	MZ-J-7-114	63	65	71	60	53
20	MZ-J-7-116	72	64	46	53	44
21	MZ-J-7-110	76	75	64	48	63
22	JV-1-36*	64	79	75	71	71
23	JV-1-65*	72	85	82	80	77

The antagonists were applied at a 30 nM concentration, except for the standard antagonist, which was applied at 100 nM.

Asterisks indicate data taken from ref. 18.