Table 1.
Akt activation correlates with permissiveness for MV
| Cell line | Cell origin | Endogenous |
p-Akt |
Permissive |
||||
|---|---|---|---|---|---|---|---|---|
| Akt | p-Akt | vMyxlac | vMyxT5KO | vMyxlac | vMyxT5KO | |||
| Controls | RK-13 | Kidney (rabbit) | + | High | + | + | + | + |
| BGMK | Kidney (primate) | + | High | + | + | + | + | |
| HEK293 | Kidney (human) | + | High | + | + | + | + | |
| Type I | HOS | Osteocarcoma | + | High | + | + | + | + |
| Caki-1 | Renal cancer | + | High | + | + | + | + | |
| PC3 | Prostate cancer | + | High | + | + | + | + | |
| Type II | HCT116 | Colon cancer | + | Low | + | − | + | − |
| 786–0 | Renal cancer | + | Low | + | − | + | − | |
| ACHN | Renal cancer | + | Low | + | − | + | − | |
| SK-OV-3 | Ovarian cancer | + | Low | + | − | + | − | |
| U373 | Glioma | + | Low | + | − | + | − | |
| Type III | MCF-7 | Breast cancer | + | None | − | − | − | − |
| COLO205 | Colon cancer | + | None | − | − | − | − | |
| MDA-MB435 | Breast cancer | + | None | − | − | − | − | |
| SK-MEL5 | Melanoma | + | None | − | − | − | − | |
+ indicates that endogenous Akt protein or phospho-Akt are detectable by immunoblotting or that cells were permissive to MV infection; − represents undetectable endogenous phosphorylated Akt Ser-473 or Thr-308, or that cells were nonpermissive to infection by MV. p-Akt, phospho-Akt.