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. 2006 Mar 14;103(12):4735–4740. doi: 10.1073/pnas.0510019103

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© 2006 by The National Academy of Sciences of the USA

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Fig. 5. — Echocardiography of 3- and 12-month-old animals. (A and B) Measurements of interventricular septum (IVS dia), posterior wall thickness (PWT dia), and calculated ratio of posterior wall thickness over left ventricular end-diastolic diameter (PWT dia/LVEDD) of 3-month-old rats (A; n = 8 per group) and 12-month-old rats (B; n = 10 per group). ∗, P < 0.05; ∗∗, P < 0.01; ∗∗∗, P < 0.001 vs. wild-type control. TG, transgenic rats; WT, wild-type control. (C and D) Left ventricular end-diastolic diameter (LVEDD), end-systolic diameter (LVESD), and ejection fraction (EF%) of 3-month-old rats (C) and 12-month-old rats (D). ∗∗∗, P < 0.001 vs. wild-type control.