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. 2006 Apr 3;7:6. doi: 10.1186/1471-2172-7-6

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Copyright © 2006 Jiang et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TSLP specifically enhances FoxP3 expression in CD4⁺CD8^-thymocytes. A: TSLP induced expression of FoxP3 in SP4, but not DP, DN and SP8 thymocytes. Purified adult thymocyte subsets were cultured with TSLP and analyzed for FoxP3 expression by RT-PCR. Relative expression of FoxP3 is shown.B: TSLP induced expression of FoxP3 in both CD4⁺CD8^-CD25^-and CD4⁺CD8^-CD25⁺SP4 thymocytes. Purified thymocytes were cultured and analyzed as above. No FoxP3 gene expression is detectable with or without TSLP in CD4^-CD8⁺CD25⁺or CD4^-CD8⁺CD25^-SP8 thymocytes.