TABLE 1 .

The effect of host MHC, parasite clone, and host gender on the time course of disease symptoms

	Disease symptom
	Parasitemia			Blood cell counts			Body weight change
	F	d.f.	P	F	d.f.	P	F	d.f.	P
Between subjects
Host MHC	9.6	2, 94	0.0002	5.2	2, 94	0.007	1.2	2, 94	0.29
Plasmodium clone	5.9	1, 94	0.017	0.1	1, 94	0.79	3.4	1, 94	0.07
Host gender	0.02	1, 94	0.89	27.8	1, 94	<0.0001	0.1	1, 94	0.77
MHC × clone	0.8	2, 94	0.43	0.5	2, 94	0.61	0.3	2, 94	0.75
MHC × gender	0.9	2, 94	0.39	1.2	2, 94	0.32	0.2	2, 94	0.82
Clone × gender	10.1	1, 94	0.002	9.5	1, 94	0.003	0.4	1, 94	0.52
MHC × clone × gender	0.7	2, 94	0.49	1.2	2, 94	0.31	1.2	2, 94	0.31
Within subjects (repeated measurements on individual mice)
Time	296.7	5, 90	<0.0001	166.1	10, 85	<0.0001	33.1	18, 77	<0.0001
Time × MHC	2.4	10, 180	0.01	1.2	20, 170	0.26	1.0	36, 154	0.46
Time × clone	6.7	5, 90	<0.0001	2.9	10, 85	0.003	1.7	18, 77	0.05
Time × gender	1.5	5, 90	0.20	1.9	10, 85	0.06	6.2	18, 77	<0.0001
Time × MHC × clone	0.4	10, 180	0.92	0.6	20, 170	0.94	1.2	36, 154	0.27
Time × MHC × gender	0.7	10, 180	0.72	1.0	20, 170	0.46	0.8	36, 154	0.78
Time × clone × gender	1.1	5, 90	0.38	1.7	10, 85	0.10	1.9	18, 77	0.03
Time × MHC × clone × gender	1.4	10, 180	0.18	0.7	20, 170	0.86	0.8	36, 154	0.72

The experiment was designed for a fully factorial repeated-measures analysis of variance (ANOVA), incorporating the fixed-effect factors “host MHC,” “host gender,” and “Plasmodium clone” with repeated measures of the following dependent variables: parasitemia (6 measurements from day 4 to day 14), blood cell counts (11 measurements from day 1 to day 22), and body weight (19 measurements from day 4 to day 22), given as differences from the weight at day 0. For within-subject analyses, we used the multivariate F-tests or Wilk's λ (when a factor had more than two levels as in “MHC”).