Figure 2. Normal production of IFN-γ in the absence of IL-23, but not IL-12.

CD4⁺ splenocytes from IL-10 –deficient mice and mice doubly deficient for IL-10 and IL-23p19 (A) or IL-12p35 (B) were stimulated with anti-CD3 and anti-CD28 for 3 days. Supernatants were assessed for IFN-γ as described in Methods. Bars represent 3 mice per group; error bars indicate SD. Data shown are representative of 2 experiments.