Figure 3. IL-23 treatment accelerates the onset of colitis in T cell–reconstituted immunodeficient recipients.

(A) Disease scores of Rag-KO mice reconstituted with naive or memory CD4⁺ T cells from IL-10 –KO donors followed by daily infusions with IL-23 (1 μg/dose) or saline for 4 weeks (n = 8). (B) T cell and accessory cell numbers in mesenteric lymph nodes of reconstituted Rag-KO mice treated with IL-23 or saline for 4 weeks.