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. 2006 May 1;116(5):1310–1316. doi: 10.1172/JCI21404

Figure 6. Blocking IL-6 and IL-17 significantly reduced the intestinal inflammation, by 50%.

Figure 6

Recipient mice were dosed i.p. with isotype, anti–IL-6, anti–IL-17, or anti–IL-6 plus anti–IL-17 Abs (2 mg/mouse) a day prior to T cell reconstitution. Rag-KO mice were reconstituted with sorted splenic CD4+CD45RBhi (naive) T cells (5 × 105 cells/mouse) from diseased IL-10 –KO mice and treated daily with 1 μg/mouse IL-23 protein. Subsequent rounds of Ab were administered weekly for 6 weeks. The graph shows the path scores from 2 independent but identical experiments. The disease scores for each group were obtained as previously described (41). Horizontal bars represent the median value for each group. **P < 0.05, compared with isotype Ab (unpaired Student’s t test). Histologic examination was performed and scored using formalin-fixed tissue sections stained with H&E, as previously described (40).