FIG. 1.

Greater disruption of the CD8-TCR Vβ repertoire as compared to CD4-TCR Vβ repertoire in HIV-infected study patients. TCR Vβ repertoire in study patients was analyzed in relation to that for normal cord blood T cells, which represent an unperturbed repertoire. The CD8-T-lymphocyte population exhibited more changes by both PCR (A) and FC (B) than the CD4 population. Box plots indicate the median value as well as 5th, 25th, 75th, and 95th percentiles. The two groups were compared using the Mann-Whitney rank sum test with a P of ≤0.05 considered significant.