TABLE 1.
Comparison of neutralizing activities at an 80% reduction of infectivity of MAbs and polyclonal antibodies among pseudotype viruses and native hantaviruses
| Antibody | Neutralizing activityb
|
||||
|---|---|---|---|---|---|
| HTNV | SEOV | VSVΔG∗HTN | VSVΔG∗SEO | VSVΔG∗G | |
| MAbsa | |||||
| G1-aa 6D4/10F11 | - | - | - | - | - |
| G1-b 2D5c/3D5/16D2c | 64 | - | 64 | - | - |
| G2-a | |||||
| HCO2 | 16 | 16 | 16 | 16 | - |
| 16E6 | 64 | - | 64 | - | - |
| G2-c 11E10-2-2 | 2 | - | 2 | - | - |
| G2-d 5B7 | - | - | - | - | - |
| G2-e 20D3 | - | - | - | - | - |
| G2-f 8E10/1C6/7G6/23G10-1 | - | - | - | - | - |
| Rabbit polyclonal antibodies | |||||
| Anti-HTNV | 320 | <40 | 320 | 40 | <40 |
| Anti-SEOV | <40 | 1,280 | 40 | 1,280 | <40 |
a
Antigenic sites were characterized by Arikawa et al. (2).
b
-, No neutralizing activity was detected at maximum concentration of MAbs (250 μg/ml). For the MAbs, values refer to the reciprocal dilution of purified MAbs (250 μg/ml) at an 80% reduction of infectivity. For the rabbit polyclonal antibodies, values indicate the reciprocal titers of rabbit immune serum at an 80% reduction of infectivity.
c
Not tested.